The nearest major airport in United States is McAllen-Miller International Airport (MFE / KMFE). This airport has international and domestic flights from McAllen, Texas and is about 121 miles from LRD.
The closest major airport to Laredo International Airport is Quetzalcóatl International Airport (NLD / MMNL). This airport is in Nuevo Laredo, Mexico and is 18 miles from LRD. If you're looking for domestic flights to NLD, check the airlines that fly to NLD.
Travelmath helps you find the closest airport to any city, as well as a list of smaller local airports. You can use these pages to plan your trip and figure out the easiest way to get to your destination. Many times there are multiple airports near the city you want to visit, so you can often find a cheaper flight into a different airport. This is especially useful if you are getting a rental car, since it might be better to drive a bit farther in order to save money on airfare. If you're booking an international flight, you probably want the closest major airport, otherwise if you're a pilot you may be looking for a local airport. Use this tool along with the flight distance pages to plan your travel.