Your total trip with all stops is around 1,530 miles / 2460 km, taking roughly 24.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between BUF and HOU.
Start from Buffalo Niagara International Airport.
Columbus, Ohio is stopping point #1 after driving about 330 miles (540 km) or 5.5 hours.
Nashville, Tennessee is stopping point #2 after driving about 380 miles (610 km) or 5.5 hours. Your total trip so far is about 710 miles or 1150 km over roughly 11 hours of driving.
Memphis, Tennessee is stopping point #3 after driving about 210 miles (340 km) or 3 hours. Your total trip so far is about 920 miles or 1490 km over roughly 14.5 hours of driving.
Shreveport, Louisiana is stopping point #4 after driving about 350 miles (560 km) or 5 hours. Your total trip so far is about 1,270 miles or 2050 km over roughly 19.5 hours of driving.
Finally, William P. Hobby Airport is your destination after driving about 260 miles (410 km) or 4.5 hours. Your total trip with all stops is around 1,530 miles or 2460 km, taking roughly 24.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.