Your total trip with all stops is around 830 miles / 1340 km, taking roughly 13 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between CAE and ORD.
Start from Columbia Metropolitan Airport.
Knoxville, Tennessee is stopping point #1 after driving about 270 miles (430 km) or 4 hours.
Lexington-Fayette, Kentucky is stopping point #2 after driving about 170 miles (270 km) or 2.5 hours. Your total trip so far is about 440 miles or 700 km over roughly 6.5 hours of driving.
Indianapolis, Indiana is stopping point #3 after driving about 190 miles (310 km) or 3 hours. Your total trip so far is about 630 miles or 1010 km over roughly 10 hours of driving.
Finally, Chicago O'Hare International Airport is your destination after driving about 210 miles (330 km) or 3 hours. Your total trip with all stops is around 830 miles or 1340 km, taking roughly 13 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.