Your total trip with all stops is around 1,000 miles / 1610 km, taking roughly 16 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between CLT and MCI.
Start from Charlotte Douglas International Airport.
Knoxville, Tennessee is stopping point #1 after driving about 230 miles (370 km) or 4 hours.
Nashville, Tennessee is stopping point #2 after driving about 180 miles (290 km) or 2.5 hours. Your total trip so far is about 410 miles or 660 km over roughly 6.5 hours of driving.
Cape Girardeau, Missouri is stopping point #3 after driving about 200 miles (330 km) or 3.5 hours. Your total trip so far is about 610 miles or 980 km over roughly 10 hours of driving.
Saint Louis, Missouri is stopping point #4 after driving about 120 miles (190 km) or 2 hours. Your total trip so far is about 730 miles or 1170 km over roughly 11.5 hours of driving.
Finally, Kansas City International Airport is your destination after driving about 270 miles (440 km) or 4.5 hours. Your total trip with all stops is around 1,000 miles or 1610 km, taking roughly 16 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.