Your total trip with all stops is around 780 miles / 1260 km, taking roughly 12.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between COU and MOB.
Start from Columbia Regional Airport.
Saint Louis, Missouri is stopping point #1 after driving about 130 miles (210 km) or 2 hours.
Jackson, Tennessee is stopping point #2 after driving about 270 miles (430 km) or 4 hours. Your total trip so far is about 400 miles or 640 km over roughly 6 hours of driving.
Meridian, Mississippi is stopping point #3 after driving about 250 miles (400 km) or 4 hours. Your total trip so far is about 650 miles or 1040 km over roughly 10 hours of driving.
Finally, Mobile Regional Airport is your destination after driving about 140 miles (220 km) or 2.5 hours. Your total trip with all stops is around 780 miles or 1260 km, taking roughly 12.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.