Your total trip with all stops is around 1,770 miles / 2840 km, taking roughly 27.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Charleston, SC and Cheyenne, WY.
Start from Charleston, South Carolina.
Knoxville, Tennessee is stopping point #1 after driving about 370 miles (600 km) or 6 hours.
Nashville, Tennessee is stopping point #2 after driving about 180 miles (290 km) or 3 hours. Your total trip so far is about 550 miles or 890 km over roughly 9 hours of driving.
Saint Louis, Missouri is stopping point #3 after driving about 310 miles (500 km) or 5 hours. Your total trip so far is about 860 miles or 1390 km over roughly 14 hours of driving.
Kansas City, Missouri is stopping point #4 after driving about 250 miles (400 km) or 4 hours. Your total trip so far is about 1,110 miles or 1790 km over roughly 18 hours of driving.
Grand Island, Nebraska is stopping point #5 after driving about 290 miles (470 km) or 4.5 hours. Your total trip so far is about 1,400 miles or 2260 km over roughly 22.5 hours of driving.
Finally, Cheyenne, Wyoming is your destination after driving about 360 miles (580 km) or 5 hours. Your total trip with all stops is around 1,770 miles or 2840 km, taking roughly 27.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.