Your total trip with all stops is around 1,000 miles / 1610 km, taking roughly 17 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Columbia, SC and Appleton, WI.
Start from Columbia, South Carolina.
Knoxville, Tennessee is stopping point #1 after driving about 260 miles (420 km) or 4.5 hours.
Lexington-Fayette, Kentucky is stopping point #2 after driving about 170 miles (270 km) or 2.5 hours. Your total trip so far is about 430 miles or 700 km over roughly 7 hours of driving.
Indianapolis, Indiana is stopping point #3 after driving about 190 miles (310 km) or 3 hours. Your total trip so far is about 620 miles or 1000 km over roughly 10 hours of driving.
Chicago, Illinois is stopping point #4 after driving about 180 miles (290 km) or 3 hours. Your total trip so far is about 800 miles or 1290 km over roughly 13 hours of driving.
Finally, Appleton, Wisconsin is your destination after driving about 200 miles (320 km) or 3.5 hours. Your total trip with all stops is around 1,000 miles or 1610 km, taking roughly 17 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.