Your total trip with all stops is around 670 miles / 1080 km, taking roughly 10 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between DEN and DSM.
Start from Denver International Airport.
Lexington, Nebraska is stopping point #1 after driving about 320 miles (510 km) or 4.5 hours.
Omaha, Nebraska is stopping point #2 after driving about 220 miles (360 km) or 3 hours. Your total trip so far is about 540 miles or 870 km over roughly 7.5 hours of driving.
Finally, Des Moines International Airport is your destination after driving about 140 miles (220 km) or 2 hours. Your total trip with all stops is around 670 miles or 1080 km, taking roughly 10 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.