Your total trip with all stops is around 780 miles / 1260 km, taking roughly 11.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between DSM and GCC.
Start from Des Moines International Airport.
Sioux Falls, South Dakota is stopping point #1 after driving about 290 miles (460 km) or 4.5 hours.
Rapid City, South Dakota is stopping point #2 after driving about 350 miles (560 km) or 5 hours. Your total trip so far is about 640 miles or 1020 km over roughly 9.5 hours of driving.
Finally, Gillette-Campbell County Airport is your destination after driving about 150 miles (240 km) or 2.5 hours. Your total trip with all stops is around 780 miles or 1260 km, taking roughly 11.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.