Your total trip with all stops is around 1,400 miles / 2260 km, taking roughly 21.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Des Moines, IA and Rochester, NH.
Start from Des Moines, Iowa.
Chicago, Illinois is stopping point #1 after driving about 330 miles (540 km) or 5 hours.
Cleveland, Ohio is stopping point #2 after driving about 340 miles (550 km) or 5.5 hours. Your total trip so far is about 680 miles or 1090 km over roughly 10.5 hours of driving.
Buffalo, New York is stopping point #3 after driving about 190 miles (310 km) or 3 hours. Your total trip so far is about 870 miles or 1400 km over roughly 13.5 hours of driving.
Springfield, Massachusetts is stopping point #4 after driving about 380 miles (600 km) or 5.5 hours. Your total trip so far is about 1,250 miles or 2010 km over roughly 19 hours of driving.
Finally, Rochester, New Hampshire is your destination after driving about 160 miles (250 km) or 2.5 hours. Your total trip with all stops is around 1,400 miles or 2260 km, taking roughly 21.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.