Your total trip with all stops is around 1,310 miles / 2100 km, taking roughly 21.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between EWR and STL.
Start from Newark Liberty International Airport.
Wheeling, West Virginia is stopping point #1 after driving about 750 miles (1210 km) or 12.5 hours.
Columbus, Ohio is stopping point #2 after driving about 130 miles (200 km) or 2 hours. Your total trip so far is about 880 miles or 1410 km over roughly 14.5 hours of driving.
Indianapolis, Indiana is stopping point #3 after driving about 180 miles (280 km) or 3 hours. Your total trip so far is about 1,050 miles or 1700 km over roughly 17.5 hours of driving.
Finally, Lambert-St. Louis International Airport is your destination after driving about 250 miles (400 km) or 4 hours. Your total trip with all stops is around 1,310 miles or 2100 km, taking roughly 21.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.