Your total trip with all stops is around 190 miles / 300 km, taking roughly 4 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between EYW and FLL.
Start from Key West International Airport.
South Miami Heights, Florida is stopping point #1 after driving about 140 miles (230 km) or 3 hours.
Finally, Fort Lauderdale-Hollywood International Airport is your destination after driving about 50 miles (80 km) or 57 minutes. Your total trip with all stops is around 190 miles or 300 km, taking roughly 4 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.