Your total trip with all stops is around 1,040 miles / 1670 km, taking roughly 16 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Grafton, WI and Charleston, SC.
Start from Grafton, Wisconsin.
Indianapolis, Indiana is stopping point #1 after driving about 300 miles (480 km) or 4.5 hours.
Knoxville, Tennessee is stopping point #2 after driving about 360 miles (580 km) or 5.5 hours. Your total trip so far is about 660 miles or 1060 km over roughly 10 hours of driving.
Columbia, South Carolina is stopping point #3 after driving about 260 miles (420 km) or 4 hours. Your total trip so far is about 920 miles or 1480 km over roughly 14 hours of driving.
Finally, Charleston, South Carolina is your destination after driving about 120 miles (190 km) or 2 hours. Your total trip with all stops is around 1,040 miles or 1670 km, taking roughly 16 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.