Your total trip with all stops is around 1,520 miles / 2450 km, taking roughly 23.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between HOU and LNS.
Start from William P. Hobby Airport.
Baton Rouge, Louisiana is stopping point #1 after driving about 280 miles (450 km) or 4.5 hours.
Birmingham, Alabama is stopping point #2 after driving about 400 miles (640 km) or 6 hours. Your total trip so far is about 680 miles or 1090 km over roughly 10.5 hours of driving.
Knoxville, Tennessee is stopping point #3 after driving about 260 miles (410 km) or 3.5 hours. Your total trip so far is about 930 miles or 1500 km over roughly 14 hours of driving.
Roanoke, Virginia is stopping point #4 after driving about 260 miles (420 km) or 4 hours. Your total trip so far is about 1,190 miles or 1920 km over roughly 18 hours of driving.
Finally, Lancaster Airport is your destination after driving about 330 miles (540 km) or 5.5 hours. Your total trip with all stops is around 1,520 miles or 2450 km, taking roughly 23.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.