Your total trip with all stops is around 850 miles / 1370 km, taking roughly 13 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Huntington, WV and Biloxi, MS.
Start from Huntington, West Virginia.
Lexington-Fayette, Kentucky is stopping point #1 after driving about 120 miles (200 km) or 2 hours.
Nashville, Tennessee is stopping point #2 after driving about 220 miles (350 km) or 3.5 hours. Your total trip so far is about 340 miles or 550 km over roughly 5.5 hours of driving.
Birmingham, Alabama is stopping point #3 after driving about 190 miles (310 km) or 3 hours. Your total trip so far is about 530 miles or 860 km over roughly 8.5 hours of driving.
Finally, Biloxi, Mississippi is your destination after driving about 320 miles (510 km) or 5 hours. Your total trip with all stops is around 850 miles or 1370 km, taking roughly 13 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.