Your total trip with all stops is around 490 miles / 780 km, taking roughly 8 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between IAH and Midland, TX.
Start from George Bush Intercontinental Airport.
Austin, Texas is stopping point #1 after driving about 170 miles (280 km) or 3 hours.
San Angelo, Texas is stopping point #2 after driving about 200 miles (330 km) or 3.5 hours. Your total trip so far is about 380 miles or 600 km over roughly 6.5 hours of driving.
Finally, Midland, Texas is your destination after driving about 110 miles (180 km) or 2 hours. Your total trip with all stops is around 490 miles or 780 km, taking roughly 8 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.