Your total trip with all stops is around 1,230 miles / 1980 km, taking roughly 20 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between ISP and TPA.
Start from Long Island MacArthur Airport.
Baltimore, Maryland is stopping point #1 after driving about 250 miles (400 km) or 4.5 hours.
Raleigh, North Carolina is stopping point #2 after driving about 320 miles (520 km) or 5 hours. Your total trip so far is about 570 miles or 920 km over roughly 9.5 hours of driving.
Jacksonville, Florida is stopping point #3 after driving about 450 miles (730 km) or 7 hours. Your total trip so far is about 1,020 miles or 1640 km over roughly 16.5 hours of driving.
Finally, Tampa International Airport is your destination after driving about 210 miles (340 km) or 3.5 hours. Your total trip with all stops is around 1,230 miles or 1980 km, taking roughly 20 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.