Your total trip with all stops is around 1,050 miles / 1680 km, taking roughly 16 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Jackson, MS and York, PA.
Start from Jackson, Mississippi.
Birmingham, Alabama is stopping point #1 after driving about 240 miles (380 km) or 3.5 hours.
Knoxville, Tennessee is stopping point #2 after driving about 260 miles (410 km) or 3.5 hours. Your total trip so far is about 490 miles or 800 km over roughly 7.5 hours of driving.
Roanoke, Virginia is stopping point #3 after driving about 260 miles (420 km) or 4 hours. Your total trip so far is about 750 miles or 1210 km over roughly 11 hours of driving.
Finally, York, Pennsylvania is your destination after driving about 290 miles (470 km) or 5 hours. Your total trip with all stops is around 1,050 miles or 1680 km, taking roughly 16 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.