Your total trip with all stops is around 2,200 miles / 3550 km, taking roughly 33 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Keizer, OR and Cape Girardeau, MO.
Start from Keizer, Oregon.
Nampa, Idaho is stopping point #1 after driving about 460 miles (740 km) or 7 hours.
Ogden, Utah is stopping point #2 after driving about 320 miles (520 km) or 4.5 hours. Your total trip so far is about 780 miles or 1260 km over roughly 11.5 hours of driving.
Cheyenne, Wyoming is stopping point #3 after driving about 440 miles (700 km) or 6.5 hours. Your total trip so far is about 1,220 miles or 1960 km over roughly 18 hours of driving.
Lincoln, Nebraska is stopping point #4 after driving about 440 miles (710 km) or 6.5 hours. Your total trip so far is about 1,660 miles or 2670 km over roughly 24.5 hours of driving.
Kansas City, Missouri is stopping point #5 after driving about 190 miles (310 km) or 3 hours. Your total trip so far is about 1,850 miles or 2980 km over roughly 27.5 hours of driving.
Finally, Cape Girardeau, Missouri is your destination after driving about 350 miles (570 km) or 5 hours. Your total trip with all stops is around 2,200 miles or 3550 km, taking roughly 33 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.