Your total trip with all stops is around 780 miles / 1250 km, taking roughly 12.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between LGA and IND.
Start from LaGuardia Airport.
Philadelphia, Pennsylvania is stopping point #1 after driving about 120 miles (190 km) or 2 hours.
Wheeling, West Virginia is stopping point #2 after driving about 340 miles (550 km) or 5.5 hours. Your total trip so far is about 460 miles or 740 km over roughly 7.5 hours of driving.
Columbus, Ohio is stopping point #3 after driving about 130 miles (200 km) or 2 hours. Your total trip so far is about 590 miles or 940 km over roughly 9.5 hours of driving.
Finally, Indianapolis International Airport is your destination after driving about 190 miles (310 km) or 3 hours. Your total trip with all stops is around 780 miles or 1250 km, taking roughly 12.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.