Your total trip with all stops is around 1,040 miles / 1670 km, taking roughly 16 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between MCO and STL.
Start from Orlando International Airport.
Gainesville, Florida is stopping point #1 after driving about 120 miles (200 km) or 2 hours.
Atlanta, Georgia is stopping point #2 after driving about 330 miles (530 km) or 5 hours. Your total trip so far is about 450 miles or 730 km over roughly 6.5 hours of driving.
Nashville, Tennessee is stopping point #3 after driving about 250 miles (400 km) or 4 hours. Your total trip so far is about 700 miles or 1130 km over roughly 10.5 hours of driving.
Evansville, Indiana is stopping point #4 after driving about 150 miles (240 km) or 2.5 hours. Your total trip so far is about 850 miles or 1370 km over roughly 13 hours of driving.
Finally, Lambert-St. Louis International Airport is your destination after driving about 180 miles (290 km) or 3 hours. Your total trip with all stops is around 1,040 miles or 1670 km, taking roughly 16 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.