Your total trip with all stops is around 1,310 miles / 2110 km, taking roughly 20.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Manhattan, KS and Ithaca, NY.
Start from Manhattan, Kansas.
Columbia, Missouri is stopping point #1 after driving about 250 miles (400 km) or 4 hours.
Indianapolis, Indiana is stopping point #2 after driving about 360 miles (580 km) or 5.5 hours. Your total trip so far is about 610 miles or 970 km over roughly 9.5 hours of driving.
Detroit, Michigan is stopping point #3 after driving about 290 miles (460 km) or 4.5 hours. Your total trip so far is about 890 miles or 1430 km over roughly 13.5 hours of driving.
Finally, Ithaca, New York is your destination after driving about 420 miles (670 km) or 6.5 hours. Your total trip with all stops is around 1,310 miles or 2110 km, taking roughly 20.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.