Stopping points from Manitowoc, Wisconsin to Florence, South Carolina:

• Start from Manitowoc, Wisconsin
• 3 hours to Chicago, Illinois after driving about 170 miles / 270 km
• 3 hours to Indianapolis, Indiana after driving about 180 miles / 300 km
• 3 hours to Lexington-Fayette, Kentucky after driving about 190 miles / 310 km
• 4.5 hours to Asheville, North Carolina after driving about 280 miles / 460 km
• 3.5 hours to Florence, South Carolina after driving about 240 miles / 380 km

Your total trip with all stops is around 1,060 miles / 1710 km, taking roughly 16.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Manitowoc, WI and Florence, SC.

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Stopping points from Manitowoc, WI to Florence, SC

Start from Manitowoc, Wisconsin.

Chicago, Illinois is stopping point #1 after driving about 170 miles (270 km) or 3 hours.

Indianapolis, Indiana is stopping point #2 after driving about 180 miles (300 km) or 3 hours. Your total trip so far is about 350 miles or 570 km over roughly 6 hours of driving.

Lexington-Fayette, Kentucky is stopping point #3 after driving about 190 miles (310 km) or 3 hours. Your total trip so far is about 540 miles or 880 km over roughly 8.5 hours of driving.

Asheville, North Carolina is stopping point #4 after driving about 280 miles (460 km) or 4.5 hours. Your total trip so far is about 830 miles or 1330 km over roughly 13 hours of driving.

Finally, Florence, South Carolina is your destination after driving about 240 miles (380 km) or 3.5 hours. Your total trip with all stops is around 1,060 miles or 1710 km, taking roughly 16.5 hours for the whole trip.

Stopping point calculator

Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.