Your total trip with all stops is around 680 miles / 1100 km, taking roughly 10.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Mount Pleasant, SC and Lancaster, PA.
Start from Mount Pleasant, South Carolina.
Raleigh, North Carolina is stopping point #1 after driving about 280 miles (450 km) or 4 hours.
Washington, District of Columbia is stopping point #2 after driving about 280 miles (450 km) or 4 hours. Your total trip so far is about 560 miles or 900 km over roughly 8.5 hours of driving.
Finally, Lancaster, Pennsylvania is your destination after driving about 120 miles (190 km) or 2 hours. Your total trip with all stops is around 680 miles or 1100 km, taking roughly 10.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.