Your total trip with all stops is around 960 miles / 1550 km, taking roughly 16 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Mount Prospect, IL and Biloxi, MS.
Start from Mount Prospect, Illinois.
Decatur, Illinois is stopping point #1 after driving about 190 miles (310 km) or 3 hours.
Cape Girardeau, Missouri is stopping point #2 after driving about 220 miles (350 km) or 4 hours. Your total trip so far is about 410 miles or 650 km over roughly 7 hours of driving.
Memphis, Tennessee is stopping point #3 after driving about 170 miles (280 km) or 2.5 hours. Your total trip so far is about 580 miles or 930 km over roughly 9.5 hours of driving.
Brandon, Mississippi is stopping point #4 after driving about 220 miles (360 km) or 3.5 hours. Your total trip so far is about 800 miles or 1290 km over roughly 13 hours of driving.
Finally, Biloxi, Mississippi is your destination after driving about 160 miles (260 km) or 3 hours. Your total trip with all stops is around 960 miles or 1550 km, taking roughly 16 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.