Your total trip with all stops is around 630 miles / 1010 km, taking roughly 10 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between ORD and TRI.
Start from Chicago O'Hare International Airport.
Indianapolis, Indiana is stopping point #1 after driving about 200 miles (330 km) or 3 hours.
Lexington-Fayette, Kentucky is stopping point #2 after driving about 190 miles (310 km) or 3 hours. Your total trip so far is about 390 miles or 630 km over roughly 6 hours of driving.
Finally, Tri-Cities Regional Airport is your destination after driving about 230 miles (380 km) or 4 hours. Your total trip with all stops is around 630 miles or 1010 km, taking roughly 10 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.