Your total trip with all stops is around 930 miles / 1500 km, taking roughly 15.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between PHL and STL.
Start from Philadelphia International Airport.
Harrisburg, Pennsylvania is stopping point #1 after driving about 120 miles (200 km) or 2 hours.
Newark, Ohio is stopping point #2 after driving about 340 miles (550 km) or 6 hours. Your total trip so far is about 470 miles or 750 km over roughly 8 hours of driving.
Indianapolis, Indiana is stopping point #3 after driving about 210 miles (340 km) or 3.5 hours. Your total trip so far is about 680 miles or 1090 km over roughly 11.5 hours of driving.
Finally, Lambert-St. Louis International Airport is your destination after driving about 250 miles (400 km) or 4 hours. Your total trip with all stops is around 930 miles or 1500 km, taking roughly 15.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.