Your total trip with all stops is around 2,500 miles / 4030 km, taking roughly 38 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Pendleton, OR and Greenville, SC.
Start from Pendleton, Oregon.
Boise, Idaho is stopping point #1 after driving about 220 miles (350 km) or 3.5 hours.
Logan, Utah is stopping point #2 after driving about 300 miles (480 km) or 4.5 hours. Your total trip so far is about 520 miles or 830 km over roughly 8 hours of driving.
Cheyenne, Wyoming is stopping point #3 after driving about 440 miles (700 km) or 7 hours. Your total trip so far is about 950 miles or 1530 km over roughly 14.5 hours of driving.
Grand Island, Nebraska is stopping point #4 after driving about 360 miles (580 km) or 5.5 hours. Your total trip so far is about 1,310 miles or 2110 km over roughly 20 hours of driving.
Kansas City, Missouri is stopping point #5 after driving about 290 miles (460 km) or 4.5 hours. Your total trip so far is about 1,600 miles or 2570 km over roughly 24.5 hours of driving.
Saint Louis, Missouri is stopping point #6 after driving about 250 miles (400 km) or 3.5 hours. Your total trip so far is about 1,850 miles or 2970 km over roughly 28 hours of driving.
Nashville, Tennessee is stopping point #7 after driving about 310 miles (500 km) or 4.5 hours. Your total trip so far is about 2,160 miles or 3470 km over roughly 32.5 hours of driving.
Finally, Greenville, South Carolina is your destination after driving about 350 miles (560 km) or 5.5 hours. Your total trip with all stops is around 2,500 miles or 4030 km, taking roughly 38 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.