Your total trip with all stops is around 570 miles / 910 km, taking roughly 9.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Pennsylvania and Indiana.
Start from Pennsylvania (PA).
Wheeling, West Virginia is stopping point #1 after driving about 260 miles (410 km) or 4.5 hours.
Columbus, Ohio is stopping point #2 after driving about 130 miles (200 km) or 2 hours. Your total trip so far is about 380 miles or 620 km over roughly 6.5 hours of driving.
Finally, Indiana (IN) is your destination after driving about 190 miles (300 km) or 3 hours. Your total trip with all stops is around 570 miles or 910 km, taking roughly 9.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.