Your total trip with all stops is around 1,010 miles / 1620 km, taking roughly 15.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Quincy, IL and Charleston, SC.
Start from Quincy, Illinois.
Saint Louis, Missouri is stopping point #1 after driving about 140 miles (220 km) or 2.5 hours.
Nashville, Tennessee is stopping point #2 after driving about 310 miles (500 km) or 4.5 hours. Your total trip so far is about 450 miles or 720 km over roughly 7 hours of driving.
Knoxville, Tennessee is stopping point #3 after driving about 180 miles (290 km) or 3 hours. Your total trip so far is about 630 miles or 1010 km over roughly 9.5 hours of driving.
Columbia, South Carolina is stopping point #4 after driving about 260 miles (420 km) or 4 hours. Your total trip so far is about 890 miles or 1430 km over roughly 13.5 hours of driving.
Finally, Charleston, South Carolina is your destination after driving about 120 miles (190 km) or 2 hours. Your total trip with all stops is around 1,010 miles or 1620 km, taking roughly 15.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.