Your total trip with all stops is around 450 miles / 720 km, taking roughly 12 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between Quito, Ecuador and Cali, Colombia.
Start from Quito, Ecuador.
Pasto, Colombia is stopping point #1 after driving about 340 km (210 miles) or 6.5 hours.
Finally, Cali, Colombia is your destination after driving about 380 km (240 miles) or 5.5 hours. Your total trip with all stops is around 720 km or 450 miles, taking roughly 12 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.