Your total trip with all stops is around 810 miles / 1300 km, taking roughly 15.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between ROS and SLA.
Start from Rosario - Islas Malvinas International Airport.
Santiago del Estero, Argentina is stopping point #1 after driving about 740 km (460 miles) or 8.5 hours.
Finally, Martín Miguel de Güemes International Airport is your destination after driving about 560 km (350 miles) or 7 hours. Your total trip with all stops is around 1300 km or 810 miles, taking roughly 15.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.