Your total trip with all stops is around 1,380 miles / 2220 km, taking roughly 21.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between RSW and BUF.
Start from Southwest Florida International Airport.
Jacksonville, Florida is stopping point #1 after driving about 330 miles (530 km) or 5 hours.
Charlotte, North Carolina is stopping point #2 after driving about 380 miles (620 km) or 5.5 hours. Your total trip so far is about 710 miles or 1140 km over roughly 10.5 hours of driving.
Pittsburgh, Pennsylvania is stopping point #3 after driving about 450 miles (720 km) or 7 hours. Your total trip so far is about 1,160 miles or 1870 km over roughly 17.5 hours of driving.
Finally, Buffalo Niagara International Airport is your destination after driving about 220 miles (360 km) or 4 hours. Your total trip with all stops is around 1,380 miles or 2220 km, taking roughly 21.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.