Your total trip with all stops is around 1,850 miles / 2980 km, taking roughly 28 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between SAN and STL.
Start from San Diego International Airport.
Phoenix, Arizona is stopping point #1 after driving about 360 miles (580 km) or 5.5 hours.
Los Lunas, New Mexico is stopping point #2 after driving about 420 miles (680 km) or 6.5 hours. Your total trip so far is about 780 miles or 1250 km over roughly 12.5 hours of driving.
Amarillo, Texas is stopping point #3 after driving about 310 miles (500 km) or 4.5 hours. Your total trip so far is about 1,090 miles or 1750 km over roughly 17 hours of driving.
Oklahoma City, Oklahoma is stopping point #4 after driving about 260 miles (420 km) or 4 hours. Your total trip so far is about 1,350 miles or 2170 km over roughly 20.5 hours of driving.
Finally, Lambert-St. Louis International Airport is your destination after driving about 500 miles (810 km) or 7.5 hours. Your total trip with all stops is around 1,850 miles or 2980 km, taking roughly 28 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.