Your total trip with all stops is around 910 miles / 1460 km, taking roughly 14 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between STL and PHL.
Start from Lambert-St. Louis International Airport.
Indianapolis, Indiana is stopping point #1 after driving about 250 miles (400 km) or 4 hours.
Columbus, Ohio is stopping point #2 after driving about 180 miles (280 km) or 2.5 hours. Your total trip so far is about 430 miles or 690 km over roughly 6.5 hours of driving.
Harrisburg, Pennsylvania is stopping point #3 after driving about 370 miles (590 km) or 6 hours. Your total trip so far is about 790 miles or 1280 km over roughly 12.5 hours of driving.
Finally, Philadelphia International Airport is your destination after driving about 110 miles (180 km) or 2 hours. Your total trip with all stops is around 910 miles or 1460 km, taking roughly 14 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.