Your total trip with all stops is around 1,180 miles / 1900 km, taking roughly 18 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between STL and RSW.
Start from Lambert-St. Louis International Airport.
Evansville, Indiana is stopping point #1 after driving about 180 miles (290 km) or 3 hours.
Nashville, Tennessee is stopping point #2 after driving about 150 miles (240 km) or 2.5 hours. Your total trip so far is about 340 miles or 540 km over roughly 5 hours of driving.
Atlanta, Georgia is stopping point #3 after driving about 250 miles (400 km) or 4 hours. Your total trip so far is about 580 miles or 940 km over roughly 9 hours of driving.
Valdosta, Georgia is stopping point #4 after driving about 230 miles (370 km) or 3.5 hours. Your total trip so far is about 810 miles or 1310 km over roughly 12.5 hours of driving.
Tampa, Florida is stopping point #5 after driving about 230 miles (370 km) or 3.5 hours. Your total trip so far is about 1,040 miles or 1680 km over roughly 15.5 hours of driving.
Finally, Southwest Florida International Airport is your destination after driving about 140 miles (220 km) or 2 hours. Your total trip with all stops is around 1,180 miles or 1900 km, taking roughly 18 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.