Your total trip with all stops is around 680 miles / 1100 km, taking roughly 10.5 hours for the whole trip. If you want to see every small town along the way, you can get a full list of cities between TPA and RDU.
Start from Tampa International Airport.
Jacksonville, Florida is stopping point #1 after driving about 210 miles (330 km) or 3.5 hours.
Savannah, Georgia is stopping point #2 after driving about 140 miles (230 km) or 2 hours. Your total trip so far is about 350 miles or 560 km over roughly 5.5 hours of driving.
Finally, Raleigh-Durham International Airport is your destination after driving about 340 miles (540 km) or 5 hours. Your total trip with all stops is around 680 miles or 1100 km, taking roughly 10.5 hours for the whole trip.
Travelmath helps you figure out where to stop when planning a long road trip from one location to another. The best stopping point for an overnight hotel stay or a break from driving often depends on how far or how long you want to drive before pausing to rest. You can find the closest city to your stopping point to look for hotels, or explore other cities and towns along the route. Use this as a road trip planner when you're driving cross-country or mapping a route with multiple stops.